The San Francisco 49ers are set to host the Tampa Bay Buccaneers in a Sunday Night Football showdown on November 19. This Week 11 matchup of the 2023 NFL season is slated to take place at Levi's Stadium in Santa Clara, California.

The game is set to kick off at 1:05 PM Pacific Time, 4:05 PM Eastern Time, and will be broadcast on FOX. An additional streaming option is also available on fuboTV.

49ers vs. Buccaneers Week 11 Odds

Here's a breakdown of the odds for the upcoming NFL Week 11 matchup between the San Francisco 49ers and Tampa Bay Buccaneers, as provided by BetMGM Sportsbook.

Moneyline:

Buccaneers: +450

49ers: -650

Spread:

Buccaneers +11.5 (-110)

49ers -11.5 (-110)

Total Points: 41.5

The moneyline designates the 49ers as significant favorites (-650), requiring a $650 bet to yield a $100 profit. Conversely, the Buccaneers, viewed as underdogs, offer a potential $450 profit on a $100 wager.

With the spread at +11.5 points for the Buccaneers and -11.5 for the 49ers, a handicap is introduced to balance the competition. Betting on the Buccaneers means they must either win or lose by less than 11.5 points, while the 49ers need to secure victory by more than 11.5 points.

The over/under for total points is set at 41.5, with a bet on the over expecting the combined points to exceed this number and a bet on the under anticipating a total below.

49ers vs. Buccaneers Week 11 Preview

The upcoming matchup will showcase teams positioned at different ends of the spectrum. The 49ers, with a 6-3 record, are tied with the Seattle Seahawks for the lead in the NFC West division.

On the other hand, the Buccaneers, holding a modest 4-5 record, currently stand in second place in the NFC South.

San Francisco has secured three victories against Tampa Bay in their recent five encounters. Over the same span, San Francisco has accumulated 125 points, whereas Tampa Bay has registered 99.

Over the past two seasons, San Francisco has suffered only two losses at home. The 49ers secured a 34-3 bounce-back victory against the Jacksonville Jaguars last Sunday, November 12.

Meanwhile, the Buccaneers are also coming off a huge 20-6 victory against the Tennessee Titans last week.

49ers vs. Buccaneers Week 11 Pick

49ers 34, Buccaneers 21

The notable returns of wide receiver Deebo Samuel and offensive tackle Trent Williams from injury played a crucial role in spanning the 49ers' three-game losing streak over the past weekend.

With these key players back, San Francisco is poised to defeat quarterback Baker Mayfield and the Buccaneers, who still have some issues to address on both sides of the ball.

San Francisco's defense also showcased the capability to stifle the Buccaneers' offense, reminiscent of their performance against the Jaguars.

Although Tampa Bay possesses a solid defense, they have encountered challenges against elite opponents lately.