A blockbuster showdown will be heading our way in Week 16 as the Tennessee Titans and the San Francisco 49ers square off in a key clash at Nissan Stadium. Who will prevail in this 49ers vs Titans game? Here's a breakdown of this important matchup.

San Francisco 49ers installed as -3.5 favorites

San Francisco's late-season surge continued on Sunday with the 49ers beating the Atlanta Falcons, 31-13, at Levi's Stadium. They have now won five of their last six games to climb up to sixth place in the NFC standings with an 8-6 record. The 49ers still have an outside shot of winning the NFC West as they just trail the reeling Arizona Cardinals by two games with three games left in the schedule.

The 49ers' offense was firing on all cylinders against the Falcons, scoring touchdowns on four consecutive drives to blow the game wide open. Jimmy Garoppolo was solid under center, completing 18 of 23 passes for 235 yards with one touchdown and no interceptions.

He got some help from the 49ers' running attack, with San Francisco racking up 162 yards on the ground. The 49ers scored a total of three rushing touchdowns against the Falcons. Jeff Wilson Jr. led the way for San Francisco, running for 110 yards and a score on 21 carries.

The 49ers will look to keep the momentum going against the Titans in Week 16. The 49ers will fancy their chances of doing just that as they have fared extremely well on the road this season. San Francisco has won five of its seven away games this campaign. They will be tested, though, by a Titans side that is 5-2 at home this season.

Tennessee Titans enter Week 16 as +3.5 underdogs

The Tennessee Titans lost for the third time in four games, suffering a gut-wrenching 19-13 defeat at the hands of the Pittsburgh Steelers in Week 15. The Titans had no answer for the Steelers' defense as they failed to score any points in the second half. That resulted in Pittsburgh turning a 10-point halftime deficit into a six-point win in the end.

It was a heartbreaking defeat for the Titans, whose lead atop the AFC South standings has now been sliced to a single game. The good news for Tennessee is that it holds the head-the-head tiebreaker over Indianapolis after sweeping their series this season. That is crucial heading into the final three weeks of the season.

The Titans will look to get their season back on track this Sunday when they host the red-hot San Francisco 49ers. For the Titans to grab the all-important win, they need to get a much-improved showing from Ryan Tannehill. He completed 23 of 32 passes for 153 yards with no touchdowns and one interception in the loss to the Steelers.

Mistakes hounded the Titans in Week 15, with Tennessee turning the ball over four times, three of which resulted in the Steelers taking over on the plus side of the field. They can ill afford to commit those same kind of errors against the Niners, who are averaging 25.7 points per game this season.

Writer's Prediction

San Francisco wins and covers the spread.

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