Tonight at 8:25 p.m. on NBC's Sunday Night Football, the Indianapolis Colts (5-2) will travel to Reliant Stadium, Houston to battle the Texans (2-5) as they try to save their season with a win over the AFC South's leading team. Live stream the game free here; Colts fans can listen to the game on 1070 The Fan, while Texans fans can hear the action on 100.3 The Bull.

Despite the vast gap in wins and losses, Indianapolis is treating this game as an opportunity to topple the AFC South champions.

"There's a saying -- to be the champ, you got to beat the champ. They're the champ," end/linebacker Robert Mathis said. "In order to get it back, we've just got to go down there and handle our business. I've been a part of some division championship teams. They're focused and they want it, it's just a matter of taking care of business. Make no mistake about it, we're not looking at their record because they are the two-time AFC South champions and we respect them as such."

Complicating matters for Indy is the loss of No. 1 wide receiver Reggie Wayne for the rest of the season with a torn ACL. Andrew Luck still has T.Y. Hilton and Darrius Heyward-Bey at his disposal, but the loss of Wayne's playmaking and leadership is tremendous.

In addition, they're facing a defense that has teeth. "They've got game-wreckers all over the place. They've got a front seven that is as good as anybody in football. They've got probably the best defensive player in football in J.J. Watt," coach Chuck Pagano said.

The Texans lost one of those "game-wreckers," though, when Brian Cushing was lost for the year. "We had to adjust to that last year," coach Gary Kubiak said. "We'll have to do that again. J.J. is already a leader, but I think it's going to call for some other guys to be vocal. I think (middle linebacker) Joe Mays has got more confidence in what he's doing."

Colts Injury Report:

Darrius Heyward-BeyWRHamstringDid Not Participate In PracticeQuestionable
Josh GordyCBGroinDid Not Participate In PracticeOut
Bjoern WernerDEFootFull Participation in PracticeProbable
Delano HowellSNeckDid Not Participate In PracticeOut
Cam JohnsonLBKneeDid Not Participate In PracticeQuestionable
Samson SateleCKneeFull Participation in PracticeProbable
Gregory TolerCBGroinDid Not Participate In PracticeOut

Texans Injury Report:

Keshawn MartinWRShoulderFull Participation in PracticeProbable
Darryl SharptonLBFootLimited Participation in PracticeProbable
Ben TateRBRibsLimited Participation in PracticeProbable
Shiloh KeoSAchillesFull Participation in PracticeProbable
Wade SmithGKneeLimited Participation in PracticeProbable
Duane BrownTToeFull Participation in PracticeProbable
Brandon BrooksGToeFull Participation in PracticeProbable
Eddie PleasantSToeFull Participation in PracticeProbable
Earl MitchellDTKneeFull Participation in PracticeProbable
Brice McCainCBKneeFull Participation in PracticeProbable
DeVier PoseyWRCalfFull Participation in PracticeProbable
Arian FosterRBHamstringFull Participation in PracticeQuestionable
Matt SchaubQBAnkleFull Participation in PracticeProbable
Derek NewtonTKneeFull Participation in PracticeProbable