Arizona Cardinals vs. Seattle Seahawks Week 11 Predictions, Picks, Odds and 2021 NFL Preview

Seattle Seahawks v Green Bay Packers
(Photo : Stacy Revere/Getty Images) GREEN BAY, WISCONSIN - NOVEMBER 14: Russell Wilson #3 of the Seattle Seahawks looks to pass during a game against the Green Bay Packers at Lambeau Field on November 14, 2021 in Green Bay, Wisconsin. The Packers defeated the Seahawks 17-0.

This coming Sunday, two NFC West teams will face each other as the Seattle Seahawks host the Arizona Cardinals in a Week 11 clash at the Lumen Field. Who will prevail in this Cardinals vs Seahawks clash? Here's a breakdown of this key divisional matchup.

Arizona Cardinals installed as -1 favorites

Now that was a shock. The NFC-leading Arizona Cardinals lost for the second time in three games, suffering a 34-10 beatdown at the hands of the Carolina Panthers. Colt McCoy struggled mightily in this contest, completing just 11 of 20 passes for 107 yards with no touchdowns and one interception.

The Cardinals installed McCoy as their starting quarterback for the second consecutive game as they remained cautious with their handling of Kyler Murray's left ankle sprain. That decision worked wonders last week against San Francisco as McCoy completed 84.6 percent of his passes for 249 yards and a touchdown.

McCoy was not able to replicate that feat against Carolina as he exited the game with a pectoral strain. Head coach Kliff Kingsbury considers McCoy as day to day but that is a main concern for the Cards with Murray's status still uncertain for the Week 11 clash against Seattle. The Cards are not in a rush to get Murray back out of the field with their bye coming in Week 12.

Kingsbury wants Murray to be fully healed for the home stretch, putting his availability for Week 11 in question. Murray suffered his ankle injury in the Week 9 loss against the Green Bay Packers. He has completed 72.7 percent of his passes for 2,276 yards with 17 touchdowns and seven interceptions in eight games played for the Cards this season.

Related Article: New York Giants vs Tampa Bay Bucs Week 11 Predictions, Picks, Odds, and MNF Preview 

Seattle Seahawks enter Week 11 as +1 underdogs

Russell Wilson's first game back from injury did not go according to plan as the Seattle Seahawks suffered a 17-0 loss to the Green Bay Packers at Lambeau Field. Wilson struggled in his much-anticipated return, completing just 20 of 40 passes for 161 yards with no touchdowns and two interceptions, both of which came in the end zone.

It was the first shutout loss for the Seahawks since September 18, 2011 when they lost 24-0 to the Pittsburgh Steelers. That transpired a year before Wilson's arrival in Seattle. Even with the Seahawks' offensive struggles, Seattle entered the fourth quarter down by just three points as the Packers also found it difficult to score in the tough conditions.

Green Bay managed to pull away in the final period to improve to 4-0 at home this season. Wilson's woes at Lambeau continued as he is now 0-5 in his career on this famed field. He has completed just 57.5 percent of his passes for 1,042 yards with four touchdowns and eight interceptions during that stretch. He has been sacked 16 times here with Wilson posting a low 64.0 QB rating against the Packers on the road.

Writer's Prediction

Seattle wins this critical NFC West matchup.

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